This study investigates the morphometric changes in the spine and trunk of middle-aged and elderly women before and after mastectomy. Utilizing a combination of radiographic imaging and clinical measurements, the research evaluates alterations in spinal curvature, trunk alignment, and overall posture resulting from the surgical intervention. The pre- and post-operative data reveal significant changes in spinal morphology and trunk positioning. This study highlights the necessity for post-mastectomy assessment and customized rehabilitation plans to address these morphometric alterations. The findings aim to enhance our understanding of the physical impact of mastectomy and inform strategies to improve post-operative recovery and quality of life for affected women.