Supplementary Table 1. Expression profile of the genes that revealed no significant differences in the prefrontal cortex (PFC) and the hippocampus (HPC) of the 5xFAD mice, at 6- and 9-month-old, assessed by RT-qPCR. Results are average ± SEM analysed by three-way ANOVA (α = 0.05) with Šídák's multiple comparisons test for the factors: Age (6 vs. 9 months), Genotype (WT vs. 5xFAD) and Region (hippocampus vs. prefrontal cortex). Supplementary Table 2. miRNA-target table for the Analyzed microRNAs and targets selected for this study. Obtained in the online platform https://www.mirnet.ca/ Supplementary Table 3. Node table for the analyzed microRNAs and targets selected for this study. We only considered miRNAs and/or targets with a node degree of at least 2. Obtained in the online platform https://www.mirnet.ca/ Supplementary Table 4. Bivariate Pearson’s correlation coefficients and respective p-values obtained between all miRNAs and genes. Supplementary Table 5. List of microRNAs analyzed by RT-qPCR and their primer sequences. Supplementary Table 6. List of genes and respective primer sequences used for mRNA analysis by RT-qPCR. Supplementary Table 7. Raw data used for correlational analysis in hippocampus (HPC) and prefrontal cortex (PFC) using the corrplot package in RStudio software.