Due to disparities in the quality and coverage of death records from SIM/DATASUS , we corrected the ovarian cancer death records for data quality and underreporting according to the following steps: Correction for quality of information: (i): proportional redistribution of 50% of deaths classified as ill-defined cause among defined natural causes by year, age group and state; (ii): proportional redistribution by year, age group and state of records classified as incomplete diagnosis of general cancer; (iii) the sum of the values obtained in the previous steps was added to the ovary cancer deaths registered in SIM/DATASUS; Correction for of information (ill-defined causes and incomplete cancer diagnosis) and coverage (underreporting): we multiplied the results of step iii by the correction factors obtained from adjusted synthetic extinct generations (SEG-adj) method by year, age group and state .

 An analysis was conducted on the effect of age, period, and cohort (APC) on ovarian cancer mortality in the South and Northeast regions of Brazil.Methods: The APC models were estimated by Poisson regression through estimable functions in women aged 30 and over residing in the states of the South and Northeast regions

10-Aug-2024Araújo Neto, Amadeu; dos Santos, Juliano; Jomar, Rafael; Cardoso Meira, Karina:It is a pleasure to accept your manuscript entitled "Ovarian cancer mortality in the states of Northeast and South Brazil (1980-2019): effect of age-period and cohort" for publication in the Ciência & Saúde Coletiva.

The study was partially funded by the Brazilian Coordination for the Improvement of Higher Education Personnel (Capes) – Funding Code 001. Karina Cardoso thanks the National Council for Scientific and Technological Development (CNPq) for the productivity grant (306652/2022-6).