Blood transfusion is a lifesaving tool for millions of patients. However, there is always a risk of transfusion transmissible infections (TTI) in the blood and its products if not properly screened. There is increasing incidence of transfusion transmitted infections (TTI including Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human immunodeficiency virus (HIV), Syphilis and malaria in developing countries. Hence, it is essential to monitor safety of blood transfusion. Aim: The aim of this study is to determine the Seroprevalence of transfusion transmitted infections in healthy blood donors in a tertiary care blood bank. Materials and Methods: A retrospective study was based on records of voluntary blood donors over a period of 6 years from January 2016 to December 2021 in a tertiary care blood bank. The serum samples were screened for Hepatitis B surface antigen (HbsAg), antibodies to Human Immunodeficiency Virus (HIV) type 1 and 2, Hepatitis C virus (HCV) and syphilis using Enzyme Linked Immunosorbent assay and rapid plasma reagin screening test. Results: Total of 57,777 donors were screened and their data were analysed. Majority of the donors were male (94.6%). The overall seroprevalence of HIV, HbsAg, HCV and Syphilis were 0.045%, 4.5%, 0.015%, 0.006%. The most common TTI prevalence was that of Hepatitis B followed by HIV. Conclusion: In our study we found a low prevalence of TTIs among voluntary blood donors. This may be due to better selection of donors. There should be public awareness regarding voluntary blood donation. Careful donor screening and selection and the use of highly sensitive tests help to reduce the TTIs.

Blood transfusion is a lifesaving tool for millions of patients. However, there is always a risk of transfusion transmissible infections (TTI) in the blood and its products if not properly screened. There is increasing incidence of transfusion transmitted infections (TTI including Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human immunodeficiency virus (HIV), Syphilis and malaria in developing countries. Hence, it is essential to monitor safety of blood transfusion. Aim: The aim of this study is to determine the Seroprevalence of transfusion transmitted infections in healthy blood donors in a tertiary care blood bank. Materials and Methods: A retrospective study was based on records of voluntary blood donors over a period of 6 years from January 2016 to December 2021 in a tertiary care blood bank. The serum samples were screened for Hepatitis B surface antigen (HbsAg), antibodies to Human Immunodeficiency Virus (HIV) type 1 and 2, Hepatitis C virus (HCV) and syphilis using Enzyme Linked Immunosorbent assay and rapid plasma reagin screening test. Results: Total of 57,777 donors were screened and their data were analysed. Majority of the donors were male (94.6%). The overall seroprevalence of HIV, HbsAg, HCV and Syphilis were 0.045%, 4.5%, 0.015%, 0.006%. The most common TTI prevalence was that of Hepatitis B followed by HIV. Conclusion: In our study we found a low prevalence of TTIs among voluntary blood donors. This may be due to better selection of donors. There should be public awareness regarding voluntary blood donation. Careful donor screening and selection and the use of highly sensitive tests help to reduce the TTIs.