Background: Studying the immune response among health care workers in different areas is crucial for understanding the risk and vaccine deployment. Our study was designed to measure the immune response in post vaccinated health care workers and evaluate the immune response with type of vaccination. So that it can help in better management of the disease. Methodology: SARS CoV-2 IgG-II levels were measured in health care workers post vaccinated with covishield and covaxin, also the effect of covid positivity on antibody response. Results: Compared to males females had significant increase in reactivity (p=0.0227) with Median value of reactivity among males was 9.96 AU/mL[ 7.31-12.31] and of females was 5.4 AU/mL[0.53-14.77]. Median value of 12.035 AU/mL[6.11-74.9] in vaccinated was significantly increased (p=0.0008) compared to median value of 1.28 AU/mL[0.52-6.43] in non-vaccinated health care workers. Significant difference [p= <0.0001] as observed covid positive health care workers as compared to covid negative with median values of 59.4 Au/mL[47.56-167] and 6.11 Au/mL[0.54-11.96]. Vaccinated and non-vaccinated health care workers tested positive for covid are had median reactivity of 231.7 AU/mL[49.03-168.56] and 9.98 AU/mL [5.27-14.69] respectively. covid negative health care workers, vaccinated had median value of reactivity of 7.37 AU/mL[5.34-18.28] as compared to 1.27 Au/mL[0.45-4.03] in non-vaccinated [p=0.0131]. Conclusion: Seroprevalence among the health care workers has a varied response. State of covid positivity, vaccination, type of vaccination and infection along with vaccination affect the Antibody response. Thus measuring the immune response will guide us in taking precautions and better management of the disease.

Background: Studying the immune response among health care workers in different areas is crucial for understanding the risk and vaccine deployment. Our study was designed to measure the immune response in post vaccinated health care workers and evaluate the immune response with type of vaccination. So that it can help in better management of the disease. Methodology: SARS CoV-2 IgG-II levels were measured in health care workers post vaccinated with covishield and covaxin, also the effect of covid positivity on antibody response. Results: Compared to males females had significant increase in reactivity (p=0.0227) with Median value of reactivity among males was 9.96 AU/mL[ 7.31-12.31] and of females was 5.4 AU/mL[0.53-14.77]. Median value of 12.035 AU/mL[6.11-74.9] in vaccinated was significantly increased (p=0.0008) compared to median value of 1.28 AU/mL[0.52-6.43] in non-vaccinated health care workers. Significant difference [p= <0.0001] as observed covid positive health care workers as compared to covid negative with median values of 59.4 Au/mL[47.56-167] and 6.11 Au/mL[0.54-11.96]. Vaccinated and non-vaccinated health care workers tested positive for covid are had median reactivity of 231.7 AU/mL[49.03-168.56] and 9.98 AU/mL [5.27-14.69] respectively. covid negative health care workers, vaccinated had median value of reactivity of 7.37 AU/mL[5.34-18.28] as compared to 1.27 Au/mL[0.45-4.03] in non-vaccinated [p=0.0131]. Conclusion: Seroprevalence among the health care workers has a varied response. State of covid positivity, vaccination, type of vaccination and infection along with vaccination affect the Antibody response. Thus measuring the immune response will guide us in taking precautions and better management of the disease.