The crude methanolic extract of aerial Indigofera gerardiana (1mg/ml) was tested for antibacterial and antifungal activities. The plant's phytochemical screening found carbohydrates, starch, steroids, glycosides, triterpenoids, and flavonoids. The crude methanolic extract, n-hexane, butanol, and aqueous fractions of Indigofera gerardiana were effective against bacteria, fungus, and leishmaniasis. The zone of inhibition (ZOI) for Escherichia coli and Staphylococcus aureus was 11mm. The ZOI is compared to imipenum, administered a single time at 3 mg/ml. The anti-fungal activity against fungal strains, including Trichophyton longifusus, Candida albicans, Microspoumcanis, and Fusarium solani, is inhibited by 60%, 50%, 50%, and 40%. Amphotericin B, a single 400µg/ml dose, was administered, and it was the standard treatment for Aspergillus flavus and miconazole for other fungal species. Keywords: Indigofera gerardiana, antibacterial activity and antifungal activity.