This research paper presents a comparative analysis of seismic resistance and cost efficiency in lift core construction using masonry wall-column systems and shear wall systems. High-rise structures' lift cores are crucial vertical conduits that provide the necessary structural stability. To support the best practices in building design and construction, the seismic performance and financial effects of various lift-core construction techniques are examined. The study compares the seismic resistance implied on a structure by lift cores built with masonry wall-column systems, which combine load-bearing masonry walls with reinforced vertical columns to lift cores built with shear wall systems, which rely on reinforced concrete to withstand lateral forces. Analytical modeling and simulation approaches are used to evaluate seismic performance in scenarios involving severe earthquakes. A variety of loads, including dead loads, live loads, partition loads, wind loads, seismic loads, and load combinations that were pursued in accordance with BNBC 2020 standards, have been applied to both types of structures. Four required metrics were evaluated for the analysis of both structures: storey drift, overturning moment, storey shear, and storey stiffness. Furthermore, a thorough cost study is performed to evaluate the two building systems' economic viability. Each method's associated material costs for the construction of the lift core are taken into account in the analysis. By conducting thorough research, we summarized that although masonry wall lift cores with columns at four corners act better resistant to seismic action, the Shear wall lift core system overall performed better as it is more economically feasible and it's decent resistant to seismic force. The findings of this study provide important insights into the trade-offs between seismic performance and cost efficiency when choosing lift-core construction techniques. The findings are intended to help engineers, architects, and developers make informed judgments about building safety and economic sustainability in seismically-prone places.