The main objective of this research was to introduce and evaluate the disintegrate property of natural excipient like starch from unripe fruits of Papaya when used in tablet formulation. Pharmaceutical excipients developed from natural sources are economic. The unripe fruit of Papaya has high level of starch content and hence used as a raw material for starch isolation. Starch was isolated from green unripe papaya fruits using 0.5 N NaOH as Lye solution. Isolated starch was evaluated and used as a disintegrant in formulation of tablet using ibuprofen as model drug by wet granulation method. Studies indicate that starch so obtained is qualitatively and quantative comparable to corn starch. The disintegration time of formulated tablet was evaluated as per Indian Pharmacopoeia and was compare with marketed tablets. Result from various evaluations suggested characteristics of papaya starch that could be used as disintegrant in formulation.