Background: A survey was conducted to evaluate the knowledge, attitude, and practice (KAP) regarding nonsteroidal anti-inflammatory drugs (NSAIDs) in community pharmacies in the southern part of Kerala. Methods: This prospective observational study involved community pharmacies in southern Kerala. We assessed KAP related to NSAIDs using a specifically designed questionnaire. Conclusion: The study revealed that knowledge about NSAIDs among pharmacists in Kerala is below average. Out of 100 randomly selected community pharmacies, it was found that pharmacists over the age of 45 generally lacked updated knowledge about NSAIDs, including new guidelines and potential side effects. Many pharmacists, primarily holding a Diploma in Pharmacy (D Pharm), were aware of NSAIDs use but were less informed about associated risks. NSAIDs such as acetaminophen and ibuprofen were often dispensed without a prescription, while others required one. Initially, the KAP regarding NSAIDs in these pharmacies was subpar. However, following targeted counseling through informational leaflets, an improvement in KAP was observed. This emphasizes the importance of continuous education and counseling for pharmacists to enhance the safe use of NSAIDs. Effective communication of risk factors and side effects significantly improved pharmacists' understanding and practice. The study underscores the crucial role of pharmacists in ensuring safe NSAID use and the positive impact of educational interventions on their knowledge and practices. Keywords: KAP, Questionnaire, Community Pharmacy