Introduction: Gallstones are responsible to produce varies histopathological changes in the gall bladder. Our aim of this study was to correlate various gallstone characteristics with the type of mucosal response in gall bladder. Materials and Methods: The observational study was conducted on 72 cholecystectomy specimens with complete gallstones. The stones were assessed for various parameter. For microscopy, sections were obtained from the fundus, body and neck of the gallbladder. Additional sections were taken from abnormal looking areas. Results: Morphological types of gallstones among the 72 cases found were as follows: 64% had mixed stones, 20% combined, 9% pigment stones, and 7% cholesterol stones. Number of stones varied from a single calculus in 30%. Majority (52 specimens) of HPE shows chronic cholecystitis. Pigment stones appears to correlate with severity of inflammation (6/16 in Grade I inflammation, 18/22 in Grade III inflammation). Conclusion: We conclude that pigment gallstones are association with severe inflammation and higher degree of fibrosis. Gall stone also leads to the gallbladder mucosa changes from cholecystitis, hyperplasia, and metaplasia to carcinoma.

Introduction: Gallstones are responsible to produce varies histopathological changes in the gall bladder. Our aim of this study was to correlate various gallstone characteristics with the type of mucosal response in gall bladder. Materials and Methods: The observational study was conducted on 72 cholecystectomy specimens with complete gallstones. The stones were assessed for various parameter. For microscopy, sections were obtained from the fundus, body and neck of the gallbladder. Additional sections were taken from abnormal looking areas. Results: Morphological types of gallstones among the 72 cases found were as follows: 64% had mixed stones, 20% combined, 9% pigment stones, and 7% cholesterol stones. Number of stones varied from a single calculus in 30%. Majority (52 specimens) of HPE shows chronic cholecystitis. Pigment stones appears to correlate with severity of inflammation (6/16 in Grade I inflammation, 18/22 in Grade III inflammation). Conclusion: We conclude that pigment gallstones are association with severe inflammation and higher degree of fibrosis. Gall stone also leads to the gallbladder mucosa changes from cholecystitis, hyperplasia, and metaplasia to carcinoma.