Co-Crystal Structures Of Usp5 Zf-Ubd And Weak Binding Compounds

Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.

Determination of crystallization conditions which allow growth of well-diffracting co-crystals of USP5 zinc finger ubiquitin binding domain (Zf-UBD) and compounds shown to bind weakly by 19F NMR and SPR assays & to solve the co-crystal structures to determine if electron density of ligands can be seen in the binding pocket of the protein domain.

Related Organizations

University of Toronto
Canada

Keywords

xray, zinc finger, usp5, structure, crystallography

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