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ZENODO
Report . 2024
License: CC BY
Data sources: ZENODO
ZENODO
Report . 2024
License: CC BY
Data sources: Datacite
ZENODO
Report . 2024
License: CC BY
Data sources: Datacite
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FORMULATION AND EVALUATION OF FLOATING TABLETS OF METOPROLOL TARTARATE BY USING NATURAL POLYMERS

Authors: S.Rohini* , M. Ramya Teja and J. N. Suresh Kumar;

FORMULATION AND EVALUATION OF FLOATING TABLETS OF METOPROLOL TARTARATE BY USING NATURAL POLYMERS

Abstract

The aim of present research work is to formulate and evaluate controlled release floating tablet of Metoprolol tartaratein view to enhance bioavailability and therapeutic action.The tablets were formulated by employing wet granulation method using PVP K 30 as binder and isopropyl alcohol as granulating fluid. The granules were evaluated for flow properties. All the formulations showed values within the prescribed limits for tests like hardness, friability and weight variation which indicate that the prepared tablets are of standard quality. All the tablets were formulated using sodium bicarbonate as effervescent agent. All the prepared formulations floated immediately after placing into the beaker and the floating was maintained more than 14 hrs. It was observed that the carbon dioxide generated from sodium bicarbonate in presence of dissolution medium(0.1N HCL) was trapped in the polymer gel matrix formed by the hydration of polymer which decreases the density(0.5) indicted that the drug release was predominantly controlled by non fickian diffusion. Based on the release rate constant and % of drug release the formulations prepared with Moringa oleifera shown prolonged retarding nature compared with the formulations prepared with Gum karayaleaves mucilage. Among all the formulations , F3 formulation containing drug and Moringa oleifera in 1:1.5 ratio was found to be optimized formulations. Key words: Metoprolol tartarate,Moringa oleifera, Gum karayal,Sodium bicarbonate

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green