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Development And Evaluation Of Enteric Coated Omeprazole Pellets 22.5% W/W

descriptionPublicationkeyboard_double_arrow_right Article 07 Jul 2018 English Publisher:Zenodo
Authors: Deepika. B*, SK China Bikari, Naga Raju Kandukoori, A. Thanga Thirupathi, K.Sujatha;

doi: 10.5281/zenodo.1307373 , 10.5281/zenodo.1307374 , 10.5281/zenodo.1307191 , 10.5281/zenodo.1307192

Development And Evaluation Of Enteric Coated Omeprazole Pellets 22.5% W/W

Abstract

The objective of the present study is to formulate and evaluate enteric coated delayed release pellets of Omeprazole. The formulations of Omeprazole delayed release pellets of were developed by enteric film coating process varying the compositions of drug loading, barrier coating and enteric coating. HPMC E5 was used as enteric polymer. The process variables were standardized and the different batches prepared were evaluated for assay/drug content, water content, acid resistance and dissolution rate. The drug dissolution profiles of Omeprazole delayed release formulations developed were compared with that of innovators product. Based on the results formulation containing enteric coating polymer and plasticizers has been selected as the best formulation developed for Omeprazole delayed release pellets. Keywords: Enteric coating, Delayed release, Omeprazole, Pellets

Keywords

Enteric coating, Delayed release, Omeprazole, Pellets

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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