Objectives: The increasingly high incidence of cardiac diseases caused by thrombosis of the arterial vessels is one of the major factors that threaten people?s health and lives around the world. Fibrinolytic agents are used to dissolve the clots in the blood vessels; however these agents have certain limitations. Herbal remedies, considered to be both safe and effective by most consumers. Coriandrum sativum has been documented as traditional treatment for cardiac diseases. Therefore, the present study was designed to investigate the effectiveness of C. sativum (Cor 32, Cor 75, Acr 2, RG 728, Cor 75) as a fibrinolytic agent for the treatment of cardiac diseases. Materials and method: The fibrinolytic activity of C. sativum varieties (Cor 32, Cor 75, Acr 2, RG 728, Cor 75) were qualitatively determined by plate and in vitro clot lysis assay. Preliminary Phytochemical analysis of flavanoids, tannins, alkaloids, saponins, resins, carbohydrates, steroids, terpenoids and glycosides were made by following standard protocol. Observation: The phytochemical analysis of the extract showed the presence of resins, glycosides, terpenoids, carbohydrates and flavanoids. The maximum fibrinolytic activity was showed by methanol extract of Cor 32 against the entire test compared with positive control (streptokinase and heparin) and negative control (distilled water). Thus, C. sativum of variety Cor 32 is suggested to have potential for pharmaceutical exploitation in the treatment of cardiovascular diseases.