Significance of Study: The application of majja basti for the management of AVN is of new of its kind in ayurveda which was not trialed before. Case representation: A pre diagnosed case of 14 years old male patient suffering from homozygous Sickle cell disease since last 5 years. Serum biochemical test CBC, shows low Hemoglobin count and elevated total leucocytes, Plain radiographs of the Right Femoral head showed hypoplasia, sclerosis, articular marginal irregularity and subarticular cystic changes. This grave disease which is discussed above remains unexposed because of many unturned pages of molecular genetics which had aroused severe morbidity and mortality in the patients which needed a full evidence based established management for its alleviation and cure. Consequently the patient developed Avascular Necrosis (AVN) which is death of the bone tissue seen as a result of late complications of SCD, Where blood supply is cut off (avascular) partially or completely to a bony area of the body, most commonly in the head of femur bone that obstruct capillaries and restrict blood flow to the distal part of bone, resulting in ischemia, pain, necrosis and often bone damage. But in ayurveda there was no encouraging management available to manage and cure this kind of complications, So keeping all this in mind, Majja Basti was applied as a trial to manage the femoral head necrosis in sickle cell disease to find a better therapy in ayurveda scince to combat its late complications which was appeared to be very efficacious and safe during the treatment period.