This record contains raw data related to the article "Self-Care and Quality of Life in Patients with Chronic Cardiovascular Diseases: the Role of Anxiety, Depression and Perceived Distress". ABSTRACT: Aim: To explore the relationship between self-care, psychological status, and quality of life in patients with chronic cardiovascular diseases. Background: Psychological disorders are frequent among patients with chronic cardiovascular diseases, who also need to perform self-care to manage their condition. Both psychological status and self-care seem to affect the quality of life, but the relationship between these three elements is not completely understood. Methods: 397 patients with chronic cardiovascular disease were enrolled. All participants completed a self-administered test battery comprising GAD-7 (symptoms of anxiety), PHQ-9 (symptoms of depression), PSS (perceived distress), EQ5D (quality of life), and SCCII (self-care). Paths analysis was conducted. Results: In people with chronic cardiovascular diseases, self-care and quality of life are indirectly linked via perceived distress as the mediating factor. Conclusions: To our knowledge, this is the first study to assess the mediating role of psyhological well-being in the relationship between self-care and quality of life in patients with chronic cardiovascular diseases. Findings indicate that, in this population, self-care affects quality of life with the moderating role of perceived distress, highlighting the importance of enhancing the cooperation between nurses and psychologists in order to alleviate distress and improve quality of life in these patients. THIS DATASET IS NOT PUBLIC. IS AVAILABLE UPON REASONABLE REQUEST TO THE CORRESPONDING AUTHOR