Human Pleckstrin Homology Domain Interacting Protein (Phip); A Target Enabling Package

SGC Oxford has expressed, purified and crystallized the second bromodomain of PHIP as part of the probe programme. Fragment screening and X-ray crystallography identified binders, some of which optimised to uM affinity. However, molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.

The work at the SGC has been supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement [115766]. This document represents version 4 of the TEP datasheet and includes all updates on the project as of June 2018. For more information about TEPs and the TEP Programme, please visit https://thesgc.org/tep.

Keywords

disease, structure discovery, infectious disease, malaria, chemical probe, chemical biology, structural genomics, metabolic diseases, drug target, drug discovery, neurological genetic disorders, oncology, target enabling package, cancer, neuropsychiatry, neuro, genetics, structure, orphan disease, protein, PHIP

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