The Transport & Logistics sector is one of the most prominent business sectors which the wide adoption of 5G cellular communications is expected to impact. The need for enhanced visibility and transparency during the execution of end-to-end logistics processes and freight transport enforces stakeholders to invest more and more in installing 5G in their businesses. In this context, the FOR-FREIGHT project targets to provide end-to-end optimization of multi-modal logistics and improved access to transshipment services through the adoption of 5G-enabled functionalities. This paper outlines the project alongside its realworld use cases, as well as an update of the progress made so far. The preliminary analysis presents the main areas of application and the expected benefits that will derive from the implementation of 5G technology in FOR-FREIGHT’s trials. In addition, correlations with other projects and potentially reusable (by FOR-FREIGHT) technologies implemented on them are identified. Moreover, an analysis of the “pain points” and the implementation barriers is conducted, regarding the installation of proper 5G connectivity in the project’s end-to-end scenarios.