Dry Eye Disease (DED) is a multifactorial condition of the ocular surface characterized by a loss of homeostasis of the tear film. It manifests with symptoms of discomfort, visual disturbance, and tear film instability. Understanding the complexities of DED is crucial for effective diagnosis and management. This review aims to provide a comprehensive overview of DED, including its causes, current treatments, and future research directions. It addresses the impact of surgical interventions, non-pharmacological therapies, complementary and alternative medicine (CAM), and the overall quality of life and economic burden associated with DED. A thorough literature review was conducted, analyzing recent studies, clinical trials, and meta-analyses related to DED. The sources included peer-reviewed journals, clinical guidelines, and evidence-based practices. The results indicate that DED is associated with various etiological factors, including surgical interventions (e.g., refractive surgery, lid surgery, cataract surgery), medications, and environmental influences. These factors contribute to tear film instability and ocular surface inflammation. In terms of treatments, surgical procedures can lead to iatrogenic DED, requiring advanced treatments like anti-inflammatory medications and nerve-stimulating agents. Non-pharmacological therapies such as warm compresses, lid massages, and punctual occlusion have proven effective in managing DED symptoms. CAM therapies, including omega-3 supplements, cyclosporine, and ginkgo biloba, show varying degrees of efficacy in alleviating DED, though the literature on CAM is limited by inconsistent results. DED significantly impacts daily activities, causing stress and anxiety, and incurs substantial economic costs related to treatment and productivity losses. Effective strategies for prevention and management include patient education, eyelid hygiene, and environmental modifications. Collaborative care between ophthalmologists and primary care physicians is essential for early detection and management. In conclusion, DED is a complex condition requiring a multifaceted management approach. Future research should focus on developing non-invasive diagnostic tools and exploring innovative treatments. Understanding DED's pathophysiology is key to improving patient outcomes and reducing the economic burden.