The spleen has a number of important functions, the main of which are participation in hematopoiesis, the immune status of the body and an important role in the hemostasis system [2, 5, 13, 18, 24]. In particular, after splenectomy there is a change in the main indicators of the vascular-platelet component of hemostasis: an increase in the number of platelets and their functional activity, including adhesive ability, the reaction of release of platelet factors is disrupted, and the retraction index decreases [7, 21]. Changes can also be traced in the coagulation link of the hemostasis system: the activated partial thromboplastin time is shortened, the concentration of fibrinogen increases, and fibrinolysis is inhibited. All this leads to the development of thrombotic complications [8, 14, 19, 26].