overview focuses on various factors that affect the scalability of parenteral, it covers different factor right from environmental factors to pakaging and also covered some shipment and handling challenges after scale up as well, we had tried to give formulators an overview that will help them to understand the scale up challenge they must consider at the time of developing the strategy to develop parenteral formulation with the intent to raise the ratio of drug discovered and comercialized, as we see out many of drug molecule discovered very little have been scaled up, the article also gives solution to many of the problems encountered although it is in general term and may vary with different molecule. Formulators can get an overview of challenges they might face during scale up so they can handle during development stage that lead to ease in scelability