Lipidomics data from knockin mice carrying a dominant negative mutation in LXRalpha (p.W441R). Wildtype, heterozygous and homozygous mice were fed either a low fat, low cholesterol control diet (TD.05230, Inotiv) or a western diet (TD.88137, Inotiv) for 8 weeks. Mice were then sacrificed and livers flash frozen. Livers were homogenised, lipids extracted and lipid profile analysed by liquid chromatography and mass spectrometry as described in Lockhart, Muso et al., (https://www.biorxiv.org/content/10.1101/2024.04.28.591512v1). If a lipid could not be detected in a sample, or quality checks were failed, values were set to half the minimum reported value. The data was then log transformed prior to upload.