Introduction: Comorbidity of physical as well as mental disorders is an important challenge for global health care. The rise in life expectancy and a number of other factors have led to an increase in its prevalence, which is predicted to continue. The relationship between depression and diabetes is a classic case of mental/physical comorbidity. Both disorders are becoming more common, and depression in persons with diabetes is twice as common as in those without diabetes. The majority of health facilities are ill-equipped to handle diabetes and depression together, and things will likely get worse as medicine becomes more specialized (and fragmented). Aim of the Study: The epidemiology and risk factors for the co-occurrence of depression and diabetes are reviewed in this study, along with areas that need to be prioritized in order to lessen issues that may arise as a result of the co-occurrence of these two disorders. Methodology: The review is a comprehensive research of PUBMED since the year 2007 to 2022. Conclusion: Diabetes and depression place a major burden on the public health system. Diabetes has a significant association with depression. Though the precise processes by which these two chronic diseases interact and significantly impair one another's quality of life are still unknown. In this article, the common causes of the comorbidity of diabetes and depression were discussed. These causes included physiological (such as the hypothalamic-pituitary-adrenal (HPA) axis' dysregulation, the sympathetic nervous system's (SNS) overactivity, microvascular dysfunction, arterial stiffening, inflammation, and cytokines), behavioral (such as dietary and lifestyle changes), and environmental (such as childhood hardship, poverty, and neighborhood conditions). Keywords: diabetes-related distress, the impact of diabetes and depression on life, diabetes and depression prevalence, depression, etc.