AbstractAim: The aim of the present study was to estimate oxidative stress and antioxidant status in tropical chronicpancreatitis (TCP) and alcoholic chronic pancreatitis (ACP) and correlate with zinc status.Methods: The present study was conducted in the Department of Gastroenterology, Big Apollo Spectra HospitalPatna, Bihar, India and Chronic pancreatitis patients were recruited for the study and was diagnosed on the basisof presence of pancreatic calcification (US/CT) and/or parenchymal or ductal changes on imaging. 100 patientswere included in the study. This study was approved by the Institutional Ethics Committee and written informedconsent was obtained from the subjects before enrollment.Results: Of the 100 patients, there were 50 TCP patients and 50 ACP patients. The mean age of all CP patientswas comparable with the age of controls; however, TCP patients were younger than ACP patients. The mean bodymass index was comparable in all three groups. The erythrocyte GSH, GPx, SOD, and plasma vitamin C levelswere lower, and erythrocyte TBARS was higher in both TCP and ACP patients as compared to healthy controls.Plasma vitamin C was lower whereas, erythrocyte TBARS was higher in TCP patients as compared to ACPpatients. Erythrocyte GSH level was significantly low in ACP as compared to TCP patients. We found lowervalues of erythrocyte GSH, GPx, SOD, and plasma vitamin C and higher erythrocyte TBARS in both diabetic andnon-diabetic CP patients as compared to healthy controls. However, we did not find differences between diabeticand non-diabetic TCP patients or between diabetic and non-diabetic ACP patients.Conclusion: The study corroborates the role of oxidative stress in CP and suggests some differences in oxidativestatus in TCP and ACP patients. Zinc deficiency appears to affect oxidative status in CP patients

AbstractAim: The aim of the present study was to estimate oxidative stress and antioxidant status in tropical chronicpancreatitis (TCP) and alcoholic chronic pancreatitis (ACP) and correlate with zinc status.Methods: The present study was conducted in the Department of Gastroenterology, Big Apollo Spectra HospitalPatna, Bihar, India and Chronic pancreatitis patients were recruited for the study and was diagnosed on the basisof presence of pancreatic calcification (US/CT) and/or parenchymal or ductal changes on imaging. 100 patientswere included in the study. This study was approved by the Institutional Ethics Committee and written informedconsent was obtained from the subjects before enrollment.Results: Of the 100 patients, there were 50 TCP patients and 50 ACP patients. The mean age of all CP patientswas comparable with the age of controls; however, TCP patients were younger than ACP patients. The mean bodymass index was comparable in all three groups. The erythrocyte GSH, GPx, SOD, and plasma vitamin C levelswere lower, and erythrocyte TBARS was higher in both TCP and ACP patients as compared to healthy controls.Plasma vitamin C was lower whereas, erythrocyte TBARS was higher in TCP patients as compared to ACPpatients. Erythrocyte GSH level was significantly low in ACP as compared to TCP patients. We found lowervalues of erythrocyte GSH, GPx, SOD, and plasma vitamin C and higher erythrocyte TBARS in both diabetic andnon-diabetic CP patients as compared to healthy controls. However, we did not find differences between diabeticand non-diabetic TCP patients or between diabetic and non-diabetic ACP patients.Conclusion: The study corroborates the role of oxidative stress in CP and suggests some differences in oxidativestatus in TCP and ACP patients. Zinc deficiency appears to affect oxidative status in CP patients