The present deliverable specifies the architecture of the DESIRE6G system. This document serves as basis for the design and system integration of a next-generation network architecture aimed at meeting the stringent requirements of future 6G applications. The DESIRE6G architecture will apply three main innovations to move towards a more service-specific and dynamic behaviour. The system will be based on a flexible and dynamic service framework that enables applications to discover, instantiate, and utilize services on a per-request basis, promoting efficient resource utilization and simplified service management. It involves multi-timescale control loops considering various inputs, such as network topology and resource utilization, along with key performance indicators (KPIs) and policies (e.g., minimizing energy consumption). These loops enable infrastructure adjustments and multi-parameter optimizations with the support of AI. And finally, all of the DESIRE6G capable sites will run an infrastructure management layer. This layer acts as a combination of the Virtualized Infrastructure Manager (VIM) and a hardware abstraction layer (HAL), facilitating the use of hybrid hardware systems and cloud-native automation in handling physical resources without complicating the upper layers, especially the business logic. The DESIRE6G system is designed to integrate these innovations into a coherent architecture capable of achieving the project’s KPIs and addressing diverse service and use case requirements. This document details the functional components, their interactions, and the processes within the DESIRE6G system, providing a roadmap for the deployment of an AI-powered, zero-touch, cloud-native 6G network that supports ultra-reliable low-latency communications (URLLC) and other critical 6G services