Background and Objectives: Medical methods emerged as an alternative to surgical abortion with the discovery of prostaglandins in the early1930. Nearly 20% of all confirmed pregnancies end in spontaneous abortion. Misoprostol’s use in early pregnancy for termination of Pregnancy its success. And failure is varied the dose and route are not well established. Studies evaluating different regimens, including combination mifepristone and misoprostol and alone regimens, show varying results related to safety, efficacy and other outcome. To study the efficacy of sublingual misoprostol in causing expulsion of products of conception in early pregnancy failure. Material and Methods: Women with an ultrasound diagnosis of early pregnancy failure, less than 12 weeks gestation were included in the study. Tablet Misoprostol 600 mcg was given six hourly sublingually for 3 doses. All observations were noted and analyzed. This study was carried out NMCH Patna. Study duration One year. Conclusion: The regime had 92.85% efficacy, acceptability (90%) and few side effects. Systemic review we find that medical methods of abortion utilizing combination mifepristone and misoprostol or misoprostol alone are effective, safe and acceptable.

Background and Objectives: Medical methods emerged as an alternative to surgical abortion with the discovery of prostaglandins in the early1930. Nearly 20% of all confirmed pregnancies end in spontaneous abortion. Misoprostol’s use in early pregnancy for termination of Pregnancy its success. And failure is varied the dose and route are not well established. Studies evaluating different regimens, including combination mifepristone and misoprostol and alone regimens, show varying results related to safety, efficacy and other outcome. To study the efficacy of sublingual misoprostol in causing expulsion of products of conception in early pregnancy failure. Material and Methods: Women with an ultrasound diagnosis of early pregnancy failure, less than 12 weeks gestation were included in the study. Tablet Misoprostol 600 mcg was given six hourly sublingually for 3 doses. All observations were noted and analyzed. This study was carried out NMCH Patna. Study duration One year. Conclusion: The regime had 92.85% efficacy, acceptability (90%) and few side effects. Systemic review we find that medical methods of abortion utilizing combination mifepristone and misoprostol or misoprostol alone are effective, safe and acceptable.