This research can contribute to elucidate this issue, in addition to subsidizing the clinical practice of health professionals and assist in the preparation of specific care protocols for this population, with peculiar clinical characteristics and little discussed in the scope of research. This study aimed to evaluate the results of studies that supplemented with vitamin D, impact of SOD on patients with CKD. Several studies have been done regarding the inhibitory effect of SARS. Mice without VDR expression have a 3-fold increased renin expression with a consequent increase in plasma angiotensin II and, clinically, arterial hypertension. In cell cultures of As 4.1 cells, with high renin synthesis, the administration of 1.25 (OH) 2D markedly decreased the activity of the promoter region of the VDR-mediated renin gene, resulting in a decrease in the respective messenger ribonucleic acid (mRNA). In mice lacking 1  - hydroxylase expression, administration of 1.25 (OH) 2D was also effective in decreasing the activation of RAAS and in the treatment of arterial hypertension. An experimental study with partially nephrectomized animal models evaluated the renal effect of administering an ACE inhibitor, enalapril, a vitamin D analogue, paricalcitol, or both. It was found that in most of the parameters studied, the combination was more effective than either of the two drugs separately.