Introduction: Thrombocytopenia is characterized by a low platelet count as a result of marrow hypo proliferation or peripheral platelet breakdown. Several diagnostic techniques have been proposed to identify the underlying cause of thrombocytopenia. The aetiology might include febrile illnesses including dengue fever and malaria, as well as other infectious diseases. The purpose of this research was to assess the clinical characteristics, mean platelet volume (MPV), and platelet distribution width (PDW) of febrile individuals with thrombocytopenia. Material and Methods: Ninety-eight cases of both genders suspected with thrombocytopenia with acute febrile infections above 21 years of age were included. 5 ml of peripheral venous blood was collected to analyse the parameters including complete blood count, platelet distribution width, and mean platelet volume were estimated and recorded. Results: The severity of thrombocytopenia was severe in 24.48%, moderate in 55.10% and mild in 20.40% of cases. The mean difference of platelet value, mean platelet volume, PWD, and PWD/PLT were statistically significant (p<0.05). Infectious conditions such as dengue fever (30.61%), malaria (10.20%), leptospira (7.14%) and other conditions (52.04%) were observed in participants. Conclusion: Mean platelet volume and platelet distribution width are the potential screening tools for diagnose and differentiating the cause of thrombocytopenia. However, Early suspicion, screening, diagnosis and prompt management of thrombocytopenia will effectively lower morbidity and mortality related dreaded illness.

Introduction: Thrombocytopenia is characterized by a low platelet count as a result of marrow hypo proliferation or peripheral platelet breakdown. Several diagnostic techniques have been proposed to identify the underlying cause of thrombocytopenia. The aetiology might include febrile illnesses including dengue fever and malaria, as well as other infectious diseases. The purpose of this research was to assess the clinical characteristics, mean platelet volume (MPV), and platelet distribution width (PDW) of febrile individuals with thrombocytopenia. Material and Methods: Ninety-eight cases of both genders suspected with thrombocytopenia with acute febrile infections above 21 years of age were included. 5 ml of peripheral venous blood was collected to analyse the parameters including complete blood count, platelet distribution width, and mean platelet volume were estimated and recorded. Results: The severity of thrombocytopenia was severe in 24.48%, moderate in 55.10% and mild in 20.40% of cases. The mean difference of platelet value, mean platelet volume, PWD, and PWD/PLT were statistically significant (p<0.05). Infectious conditions such as dengue fever (30.61%), malaria (10.20%), leptospira (7.14%) and other conditions (52.04%) were observed in participants. Conclusion: Mean platelet volume and platelet distribution width are the potential screening tools for diagnose and differentiating the cause of thrombocytopenia. However, Early suspicion, screening, diagnosis and prompt management of thrombocytopenia will effectively lower morbidity and mortality related dreaded illness.