Introduction: The Guillain-Barre syndrome (GBS) is an acute immune-mediated neuropathy and is recognized clinically by the presence of acute, rapidly progressive flaccid weakness, diminished or absent reflexes and albumin cytological dissociation in cerebrospinal fluid. Each subtype may have a different immunopathogenesis therefore, may have different approach treatments hence identification of these subtypes is important. The aims of the study were to identify the incidence of patients meeting electrophysiological criteria for demyelinating or axonal subtypes based on the well-established Rajabally’s criteria. Materials and Methods: All patients aged clinically diagnosed as GBS and meeting the Brighton diagnostic criteria for diagnosis of GBS were included in the study. Retrospective analysis of clinical and electrophysiological data of 50 Guillaine barre syndrome (GBS) patients of the Thanjavur Medical College, Thanjavur were done. Results: Age of the patients ranged from 10-70 years with mean age of 37.8 years of age in this study. Flaccid weakness was present in almost all patients. On analysing electrophysiologic pattern of GBS patient’s 58 percent showed pure demyelination and 12% of patients showed pure axonal pattern with 14 percent of patients showed either of the patterns. Conclusion: Our study was showing predominantly demyelinating variant note in 72 percent of patients and F wave abnormalities were noted in 56% of patients. suggesting a slight preponderance of AIDP (acute inflammatory demyelinating polyneuropathy) variety in India. Early detection and characterization of GBS in is useful in timely intervention to reduce morbidity and disability and also useful to assess the prognosis.

Introduction: The Guillain-Barre syndrome (GBS) is an acute immune-mediated neuropathy and is recognized clinically by the presence of acute, rapidly progressive flaccid weakness, diminished or absent reflexes and albumin cytological dissociation in cerebrospinal fluid. Each subtype may have a different immunopathogenesis therefore, may have different approach treatments hence identification of these subtypes is important. The aims of the study were to identify the incidence of patients meeting electrophysiological criteria for demyelinating or axonal subtypes based on the well-established Rajabally’s criteria. Materials and Methods: All patients aged clinically diagnosed as GBS and meeting the Brighton diagnostic criteria for diagnosis of GBS were included in the study. Retrospective analysis of clinical and electrophysiological data of 50 Guillaine barre syndrome (GBS) patients of the Thanjavur Medical College, Thanjavur were done. Results: Age of the patients ranged from 10-70 years with mean age of 37.8 years of age in this study. Flaccid weakness was present in almost all patients. On analysing electrophysiologic pattern of GBS patient’s 58 percent showed pure demyelination and 12% of patients showed pure axonal pattern with 14 percent of patients showed either of the patterns. Conclusion: Our study was showing predominantly demyelinating variant note in 72 percent of patients and F wave abnormalities were noted in 56% of patients. suggesting a slight preponderance of AIDP (acute inflammatory demyelinating polyneuropathy) variety in India. Early detection and characterization of GBS in is useful in timely intervention to reduce morbidity and disability and also useful to assess the prognosis.