Bacterial resistance to antibacterial agents is of grave concern in the medical community, as many species of bacteria haveevolved as resistant strains. In the present study a series of novel 2-aryl substituted benzothiazoles were synthesized. Thesynthesized benzothiazole derivatives were characterized physicochemically, by elemental analysis and spectral (IR and1H-NMR) analysis. All the synthesized compounds were screened for their in-vitro antibacterial activity against Grampositive and Gram-negative bacteria. The results revealed that most of the compounds have better activity againstStaphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa as compared with the standardGentamicin and Amoxycillin and less active than the standard Ciprofloxacin. Further research can warrant moreconsideration on benzothiazoles as prospective antimicrobials.

Bacterial resistance to antibacterial agents is of grave concern in the medical community, as many species of bacteria haveevolved as resistant strains. In the present study a series of novel 2-aryl substituted benzothiazoles were synthesized. Thesynthesized benzothiazole derivatives were characterized physicochemically, by elemental analysis and spectral (IR and1H-NMR) analysis. All the synthesized compounds were screened for their in-vitro antibacterial activity against Grampositive and Gram-negative bacteria. The results revealed that most of the compounds have better activity againstStaphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa as compared with the standardGentamicin and Amoxycillin and less active than the standard Ciprofloxacin. Further research can warrant moreconsideration on benzothiazoles as prospective antimicrobials.