Introduction: Leprosy is one of the most ancient diseases known to mankind. It is a chronic,debilitating, granulomatous disease caused by Mycobacterium Leprae principally affectingthe cooler parts of the body, mainly skin and peripheral nerves. Leprosy reactions areimmunologically mediated episodes of acute or subacute inflammation which interrupt thenatural course of disease affecting the skin, nerves and others tissues. Reactional states aredivided into two forms, called type I and type II reactions. Material and Methods: Presentstudy was carried out in patients attending the Outpatient and Inpatient, Department ofdepartment of DVL Index Medical College, Indore from January 2015 to December 2018.Gross examinations of biopsies were done and Histopathological features and thebacteriological status were noted and the diagnosis of leprosy was confirmed and classifiedaccording to Ridley and Jopling classification. Results: Out of total 50 patients, 19 patientswere of Type I reaction while 31 of Type II reaction. Among 19 type I reaction patients, 14were of Borderline Tuberculoid, 03 of Mid Borderline while 2 were of BorderlineLepromatous, thus BT patients had higher incidence of type I reaction. Among 31 type IIpatients 20 were of lepromatous leprosy while rest 11 of borderline lepromatous.Conclusion: In the present study prevalence of type II Lepra reaction was higher than type ILepra reaction. This study emphasizes the need for detailed history, clinical examination andinvestigations including biopsy for timely recognition of reactions, in order to halt theprogress and prevent the permanent damage it causes.

Introduction: Leprosy is one of the most ancient diseases known to mankind. It is a chronic,debilitating, granulomatous disease caused by Mycobacterium Leprae principally affectingthe cooler parts of the body, mainly skin and peripheral nerves. Leprosy reactions areimmunologically mediated episodes of acute or subacute inflammation which interrupt thenatural course of disease affecting the skin, nerves and others tissues. Reactional states aredivided into two forms, called type I and type II reactions. Material and Methods: Presentstudy was carried out in patients attending the Outpatient and Inpatient, Department ofdepartment of DVL Index Medical College, Indore from January 2015 to December 2018.Gross examinations of biopsies were done and Histopathological features and thebacteriological status were noted and the diagnosis of leprosy was confirmed and classifiedaccording to Ridley and Jopling classification. Results: Out of total 50 patients, 19 patientswere of Type I reaction while 31 of Type II reaction. Among 19 type I reaction patients, 14were of Borderline Tuberculoid, 03 of Mid Borderline while 2 were of BorderlineLepromatous, thus BT patients had higher incidence of type I reaction. Among 31 type IIpatients 20 were of lepromatous leprosy while rest 11 of borderline lepromatous.Conclusion: In the present study prevalence of type II Lepra reaction was higher than type ILepra reaction. This study emphasizes the need for detailed history, clinical examination andinvestigations including biopsy for timely recognition of reactions, in order to halt theprogress and prevent the permanent damage it causes.