Introduction: Hyperuricemia is a condition characterized by abnormally elevated levels of serum uric acid. Symptoms are those of gout and nephrolithiasis. The gold standard for diagnosis of gout is identification of monosodium urate crystals in the synovial fluid, that is painful and leads to complications like joint effusion. In recent years with advancement of ultrasonography and dual energy computed tomography (DECT) new clinical picture and staging has been identified. The present study had been designed to study the clinical profile of hyperuricemia patients with regards to joint involvement as assessed by DECT and USG and comorbidities. Aim: To study the clinical profile of hyperuricemia patients with regards to joint involvement as assessed by DECT and USG and comorbidities. Material and Method: This was a cross sectional study which was done in Era’s Lucknow Medical College & Hospital, Lucknow. The study was carried out on diagnosed hyperuricemia patients attending the medicine OPD and indoor patients of Era’s Lucknow Medical College & Hospital in the last 18 months were included in the study till the required sample size was achieved. The overall sample size consisted of 66 cases of hyperuricemia. Results: The age of patients ranged from 36 to 87 years. Majority of the cases were aged more than 60 years. Further, majority of patients were females (56.1%). Only 19 (28.8%) patients were symptomatic with symptoms of pain, swelling and tenderness at joints were reported. Six patients had no comorbidities while rest 60 patients reported comorbidities. Diabetes alone (15.2%) was most common comorbidity. The radiological evidence of abnormalities which were indicative of involvement of joint by USG were DCS or HAG which were observed in 45.5% patients. MSU crystals were observed in 39.1% cases by DECT. So overall radiological evidence of joint involvement was found in 56.1% cases. No significant association of joint involvement was found with no of comorbidities, CAD, hypertension, T2DM and dyslipidemia. Significant association of S. uricemic acid was found only with joint involvement indicated by radiological findings. Conclusion: On the basis of these findings, it can be inferred that that asymptomatic patients (especially females and older) of hyperuricemia are at risk of developing joint involvement who should be radiologically examined. The overall prevalence of joint involvement in hyperuricemia patients was lying in the range (44.13 – 68.07) with 95% confidence. A confirmed relationship of Sr Uric Acid Levels (mg/dl) with Joint Involvement was found.

Introduction: Hyperuricemia is a condition characterized by abnormally elevated levels of serum uric acid. Symptoms are those of gout and nephrolithiasis. The gold standard for diagnosis of gout is identification of monosodium urate crystals in the synovial fluid, that is painful and leads to complications like joint effusion. In recent years with advancement of ultrasonography and dual energy computed tomography (DECT) new clinical picture and staging has been identified. The present study had been designed to study the clinical profile of hyperuricemia patients with regards to joint involvement as assessed by DECT and USG and comorbidities. Aim: To study the clinical profile of hyperuricemia patients with regards to joint involvement as assessed by DECT and USG and comorbidities. Material and Method: This was a cross sectional study which was done in Era’s Lucknow Medical College & Hospital, Lucknow. The study was carried out on diagnosed hyperuricemia patients attending the medicine OPD and indoor patients of Era’s Lucknow Medical College & Hospital in the last 18 months were included in the study till the required sample size was achieved. The overall sample size consisted of 66 cases of hyperuricemia. Results: The age of patients ranged from 36 to 87 years. Majority of the cases were aged more than 60 years. Further, majority of patients were females (56.1%). Only 19 (28.8%) patients were symptomatic with symptoms of pain, swelling and tenderness at joints were reported. Six patients had no comorbidities while rest 60 patients reported comorbidities. Diabetes alone (15.2%) was most common comorbidity. The radiological evidence of abnormalities which were indicative of involvement of joint by USG were DCS or HAG which were observed in 45.5% patients. MSU crystals were observed in 39.1% cases by DECT. So overall radiological evidence of joint involvement was found in 56.1% cases. No significant association of joint involvement was found with no of comorbidities, CAD, hypertension, T2DM and dyslipidemia. Significant association of S. uricemic acid was found only with joint involvement indicated by radiological findings. Conclusion: On the basis of these findings, it can be inferred that that asymptomatic patients (especially females and older) of hyperuricemia are at risk of developing joint involvement who should be radiologically examined. The overall prevalence of joint involvement in hyperuricemia patients was lying in the range (44.13 – 68.07) with 95% confidence. A confirmed relationship of Sr Uric Acid Levels (mg/dl) with Joint Involvement was found.