This dataset contains skin conductance responses (SCR), electrocardyogram (ECG), respiration, pupil size (PSR), and gaze coordinates measurements for 34 healthy unmedicated participants (20 females and 14 males aged 24.9 +/- 4.1) participating in a Pavlovian differential cued rewarding conditioning experiment with 2 sessions. CSs were isoluminant colored triangles presented on the screen center with grey background.US was a sip of the favourite juice selected individually. SOA between the CS onset and US was 5.5 s. Participants underwent the conditioning task with CSs (CS+ 50% reinforced) and US delivery in session 1 with 2 blocks, and were tested in a retention/extinction task one week later in session 2 with 2 blocks. No US was delivered during session 2. The ITI was jittered on each trial uniformly at random between 9 to 16 s. The blocks in each session were recorded on the same day with self-paced breaks.

This work was supported by the Clinical Research Priority Program of the University of Zurich for the CRPP "Synapse & Trauma" and the Economic and Social Research Council (ES/W000776/1).