Clust&See3.0 is the novel version of a Cytoscape app that has been developed to identify, visualize and manipulate network clusters and modules, newly enriched with functionalities allowing custom annotations of nodes and computation of their statistical enrichments. As the wealth of multi-omics data is growing, such functionalities are highly valuable for a better understanding of biological module composition. go_annot.txt : The protein annotation file extracted from Gene Ontology Biological Process database. HuRI_CC.txt : The network file containing the largest connect component of the human reference interactome network [1] [1] Luck K, Kim D-K, Lambourne L, Spirohn K, Begg BE, Bian W, et al. A reference map of the human binary protein interactome. Nature. 2020;580:402–8.