AbstractAim: The aim of the present study was to explore the extent of coagulation profile derangements, its correlationwith the severity of TBI, and clinical outcome.Methods: The study was performed on patients with isolated head injury in department of General Surgery forone year . A total of 100 patients in the age group of 20 to 70 years were studied.Results: Majority of the patients belonged to the age group 41-50 years followed by 51-60 years. 80% were maleand 20% were females in the present study. Road traffic accident was the primary (75%) mode of injury. Inpatients with MHI, 64% of the study population had coagulopathy while 48% of the patients with SHI were foundto have coagulation abnormalities. The patients with SHI were divided into two groups. The first group included40 patients and had GOS 1 or GOS 2. The second group included 8 patients and had GOS 5. p-Value for DICscore was < 0.001 and is statistically significant. p-Value in both PT and APTT was < 0.05 and was significant.However, it was not significant for D-dimer, fibrinogen, and platelet counts. In patients with MHI, p-value in caseof DIC score, platelet count, APTT, and D-dimer was < 0.001 and was highly significant. p-Value in PT was <0.05 and found to be statistically significant, however, it was not significant for fibrinogen.Conclusion: The patients of isolated head injury are at high risk of developing coagulation abnormalities.Coagulopathy is directly associated with the severity of TBI, GCS, and is independently associated with pooroutcome. DIC score is a useful parameter in the prediction of prognosis of head injury patients. The timelyintervention in such patients can help improve prognosis. The analysis of coagulation parameters are usefulpredictors of outcome and can be used to explain the relatives about prognosis and course of the patient duringthe hospital stay

AbstractAim: The aim of the present study was to explore the extent of coagulation profile derangements, its correlationwith the severity of TBI, and clinical outcome.Methods: The study was performed on patients with isolated head injury in department of General Surgery forone year . A total of 100 patients in the age group of 20 to 70 years were studied.Results: Majority of the patients belonged to the age group 41-50 years followed by 51-60 years. 80% were maleand 20% were females in the present study. Road traffic accident was the primary (75%) mode of injury. Inpatients with MHI, 64% of the study population had coagulopathy while 48% of the patients with SHI were foundto have coagulation abnormalities. The patients with SHI were divided into two groups. The first group included40 patients and had GOS 1 or GOS 2. The second group included 8 patients and had GOS 5. p-Value for DICscore was < 0.001 and is statistically significant. p-Value in both PT and APTT was < 0.05 and was significant.However, it was not significant for D-dimer, fibrinogen, and platelet counts. In patients with MHI, p-value in caseof DIC score, platelet count, APTT, and D-dimer was < 0.001 and was highly significant. p-Value in PT was <0.05 and found to be statistically significant, however, it was not significant for fibrinogen.Conclusion: The patients of isolated head injury are at high risk of developing coagulation abnormalities.Coagulopathy is directly associated with the severity of TBI, GCS, and is independently associated with pooroutcome. DIC score is a useful parameter in the prediction of prognosis of head injury patients. The timelyintervention in such patients can help improve prognosis. The analysis of coagulation parameters are usefulpredictors of outcome and can be used to explain the relatives about prognosis and course of the patient duringthe hospital stay