
Súhrn Lipidomika je vedný obor, ktorý sa zaoberá štúdiom biochemických dráh lipidov v biologických systémoch. Ide o novú subšpecializáciu klinickej biochémie, ktorá je podložená výsledkami najmä hmotnostnej spektrometrie. V poslednom desaťročí sa nahromadili dôkazy o úlohe ceramidov a fosfolipidov ako možných mediátorov ateroklerózou podmienených kardiovaskulárnych ochorení (ASKVO) alebo prognostických biomarkerov. Kombinácia plazmatickej hladiny ceramidov a fosfolipidov zlepšuje predpoveď ASKVO. CERT1 a CERT2 sú nové skórovacie systémy v predpovedi koronárneho rizika na základe stanovenia špecifických ceramidov a fosfolipidov hmotnostnou spektrometriou. Kľúčové slová: ceramidy; fosfolipidy; hmotnostná spektrometria; skórovací systém; ateroskleróza; kardiovaskulárne ochorenie Abstract Lipidomics is the branch of science that deals with the study of the biochemical pathways of lipids in biological systems. Lipidomics is a new sub-specialty of clinical biochemistry using mainly mass spectrometry. In the last decade, evidence has accumulated for the role of ceramides and phospholipids as possible mediators of atherosclerosis-related cardiovascular disease (ARVD) or prognostic biomarkers. The combination of plasma ceramide and phospholipid levels improves the prediction of ASKVO events. CERT1 and CERT 2 are novel scoring systems in the prediction of coronary risk based on the determination of specific ceramides and phospholipids by mass spectrometry. Key words: ceramides; phospholipids; mass spectrometry; scoring system; atherosclerosis; cardiovascular disease
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