Background: This rational pharmacotherapeutic appraisal study was conducted to assess the maintenance of the various aspects of rational pharmacotherapeutics, including appropriateness, efficacy, safety, availability, and ease of administration in prescribing different anti-tubercular drugs, like ofloxacin, delamanid or bedaquiline, which reflected upon the prescription percentages of these drugs, thus delineating the choice of drugs, treatment regimens and the routine prescription patterns of anti-tubercular monotherapy or combination therapies, among multi-drug resistant tuberculosis patients, in multi-centre tertiary patientcare hospitals. Aim and Objectives: This rational pharmacotherapeutic research study was conducted to interprete the prescription patterns of anti-tubercular drugs monotherapy or combination therapies, among multi drug-resistant tuberculosis patients at tertiary patientcare hospitals. Materials and Methods: From the clinical prescriptions of 102 multi drug-resistant patients, thorough patients’ history with complete examination details and the prescription patterns were obtained with the study proforma, and the study data were observed, thoroughly analysed and recorded. For 24-48 weeks, these patients had been prescribed anti-tubercular drugs, like delamanid 100 mg twice daily, ofloxacin 400 mg twice daily, and bedaquiline 400 mg four times daily followed by 200 mg thrice weekly, as part of MDR-TB treatment regimens. The number of prescriptions for each drug were recorded, and the corresponding prescription rates were statistically derived in percentages. Results: The prescription frequency of delamanid was followed by ofloxacin and bedaquiline. Conclusion: Delamanid was more commonly prescribed anti-tubercular drug, followed by ofloxacin, which was less commonly prescribed, and finally followed by bedaquiline, which was the least prescribed anti-tubercular drug.

Background: This rational pharmacotherapeutic appraisal study was conducted to assess the maintenance of the various aspects of rational pharmacotherapeutics, including appropriateness, efficacy, safety, availability, and ease of administration in prescribing different anti-tubercular drugs, like ofloxacin, delamanid or bedaquiline, which reflected upon the prescription percentages of these drugs, thus delineating the choice of drugs, treatment regimens and the routine prescription patterns of anti-tubercular monotherapy or combination therapies, among multi-drug resistant tuberculosis patients, in multi-centre tertiary patientcare hospitals. Aim and Objectives: This rational pharmacotherapeutic research study was conducted to interprete the prescription patterns of anti-tubercular drugs monotherapy or combination therapies, among multi drug-resistant tuberculosis patients at tertiary patientcare hospitals. Materials and Methods: From the clinical prescriptions of 102 multi drug-resistant patients, thorough patients’ history with complete examination details and the prescription patterns were obtained with the study proforma, and the study data were observed, thoroughly analysed and recorded. For 24-48 weeks, these patients had been prescribed anti-tubercular drugs, like delamanid 100 mg twice daily, ofloxacin 400 mg twice daily, and bedaquiline 400 mg four times daily followed by 200 mg thrice weekly, as part of MDR-TB treatment regimens. The number of prescriptions for each drug were recorded, and the corresponding prescription rates were statistically derived in percentages. Results: The prescription frequency of delamanid was followed by ofloxacin and bedaquiline. Conclusion: Delamanid was more commonly prescribed anti-tubercular drug, followed by ofloxacin, which was less commonly prescribed, and finally followed by bedaquiline, which was the least prescribed anti-tubercular drug.