Background and Aim: Several pharmaceutical and non-pharmacological methods have been used to lessen the hemodynamic response to laryngoscopy and endotracheal intubation. The current study set out to determine whether Lignocaine (1 mg/kg), Dexmedetomidine (0.5 mcg/kg), or a combination of these two low dosages (Dexmedetomidine and Lignocaine) would be more successful in lowering the hemodynamic response to intubation. Material and Methods: 150 total ASA grades After receiving approval from the institutional ethical committee, 1 patients between the ages of 18 and 60 were enrolled for the study. By using the envelope method, patients were sorted into three groups of 50 each: Group L, Group D, and Group DL. Vital indicators such HR, SAP, DAP, and MAP were measured at baseline, following the administration of the study drug, during induction, and 1, 3, 5, 7, and 15 minutes after intubation. Results: It was discovered that for the whole 15-minute study period following intubation, the mean HR and BP in group DL stayed below baseline values. Conclusion: It is generally known that BP and, to a lesser extent, HR fluctuations that are more than 20–25% from baseline may be harmful. Therefore, it is vital to keep an eye out for this alteration even when the findings are within the usual range. A combination of low dose dexmedetomidine (0.5 mcg/kg) and lignocaine (1 mg/kg) effectively reduces the pressor response during laryngoscopy and intubation without having any negative hemodynamic effects, as opposed to lignocaine (1.5 mg/kg) alone or a high dose of dexmedetomidine (1 mcg/kg) alone.

Background and Aim: Several pharmaceutical and non-pharmacological methods have been used to lessen the hemodynamic response to laryngoscopy and endotracheal intubation. The current study set out to determine whether Lignocaine (1 mg/kg), Dexmedetomidine (0.5 mcg/kg), or a combination of these two low dosages (Dexmedetomidine and Lignocaine) would be more successful in lowering the hemodynamic response to intubation. Material and Methods: 150 total ASA grades After receiving approval from the institutional ethical committee, 1 patients between the ages of 18 and 60 were enrolled for the study. By using the envelope method, patients were sorted into three groups of 50 each: Group L, Group D, and Group DL. Vital indicators such HR, SAP, DAP, and MAP were measured at baseline, following the administration of the study drug, during induction, and 1, 3, 5, 7, and 15 minutes after intubation. Results: It was discovered that for the whole 15-minute study period following intubation, the mean HR and BP in group DL stayed below baseline values. Conclusion: It is generally known that BP and, to a lesser extent, HR fluctuations that are more than 20–25% from baseline may be harmful. Therefore, it is vital to keep an eye out for this alteration even when the findings are within the usual range. A combination of low dose dexmedetomidine (0.5 mcg/kg) and lignocaine (1 mg/kg) effectively reduces the pressor response during laryngoscopy and intubation without having any negative hemodynamic effects, as opposed to lignocaine (1.5 mg/kg) alone or a high dose of dexmedetomidine (1 mcg/kg) alone.