The objectives of this review to explore the research study available relating to identify the pain relieving measures and their effect during intravenous cannulation. The data were collected from the Pub Med, Google Scholar, Pro Quest, CINHAL (Cumulative index To Nursing & Allied Health Literature), MEDLINE (Medical Literature Analysis & Retrieval System Online), Science Direct by Review of literature search. The literature review concluded that Numerical rating scale is more effective pain scale. In Intra venous cannulation pain reduction many techniques were found effective like, flash light, valsava maneuver, laser assisted anesthesia, vapocoolant spray, EMLA cream and cannula site selection etc. It was found that there is no relationship between cannula material on pain reduction in Intra venous cannulation.