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Conference object . 2018
License: CC BY
Data sources: Datacite
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ZENODO
Other literature type . 2018
License: CC BY
Data sources: ZENODO
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ZENODO
Conference object . 2018
License: CC BY
Data sources: Datacite
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Advances In Understanding And Drug Development For Alk2/Acvr1 Gain Of Function Mutations In Diffuse Intrinsic Pontine Glioma (Dipg)

descriptionPublicationkeyboard_double_arrow_right Conference object , Other literature type 14 May 2018Publisher:Zenodo
Authors: Wong, Jong Fu; Brown, Elizabeth; Williams, Eleanor; Adamson, Ros; Farnie, Gillian; Boudhar, Aicha; Brennan, Paul E; +2 Authors

doi: 10.5281/zenodo.1246855 , 10.5281/zenodo.1246854

Advances In Understanding And Drug Development For Alk2/Acvr1 Gain Of Function Mutations In Diffuse Intrinsic Pontine Glioma (Dipg)

Abstract

Funding Acknowledgment: The SGC is a registered charity (number 1097737) that receives funds from AbbVie, Bayer Pharma AG, Boehringer Ingelheim, Canada Foundation for Innovation, Eshelman Institute for Innovation, Genome Canada through Ontario Genomics Institute [OGI-055], Innovative Medicines Initiative (EU/EFPIA) [ULTRA-DD grant no. 115766], Janssen, Merck KGaA, Darmstadt, Germany, MSD, Novartis Pharma AG, Ontario Ministry of Research, Innovation and Science (MRIS), Pfizer, São Paulo Research Foundation-FAPESP, Takeda, and Wellcome.

A poster outlining the program being undertaken within the Structural Genomics Consortium to co-develop drugs for both Diffuse Intrinsic Pontine Glioma (DIPG) and Fibrodysplasia Ossificans Progressiva (FOP). The following topics are covered: prevalency of ALK2/ACVR1 mutations in DIPG, the crystal structure of the ALK2-FKBP12 complex, the increased BMP pathway activity in ALK2 mutants, the M4K Pharma ALK2 inhibitor development workflow and the M4K mission statement "Affordable Meds 4 Kids".

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Keywords

CRUK brain tumour conference 2018, M4K Pharma, DIPG, diffuse intrinsic pontine glioma, kinase inhibitors, ALK2, ACVR1, inhibitor development

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selected citations
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This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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