Gruzevskiy А. А. Indicators of the hormonal regulation system in colonization resistance of vaginals. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2018;1(51):84-90. ISSN 1818-9385 DOI http://dx.doi.org/10.5281/zenodo.1239467 http://aptm.org.ua INDICATORS OF THE HORMONAL REGULATION SYSTEM IN COLONIZATION RESISTANCE OF VAGINALS Gruzevskiy А. А. Odessa National Medical University Relevance. Nonspecific inflammatory diseases of internal female genital organs occupy one of the main places in the structure of gynecological pathology. Vaginal microflora is an indicator of a woman's health status, representing a dynamic system that reacts to a change in the hormonal and immunological status under various pathological conditions. Normal vaginal microflora is divided into obligate (resident, indigenous), facultative and transient. The goal — is to study the parameters of hormonal regulation in patients under normocenosis, dysbiosis of different degrees and bacterial vaginosis. Materials and methods of research The study was conducted in 298 women aged 16 to 64 years. 53 of whom were diagnosed with normocenosis, and 245 had dysbiosis. The results of the study and their discussion In the conditions of progression of dysbiosis the primary hypergonadotropic hypogonadism developed and intensified, the cause of which could be the development of an ascending infection and involvement in the inflammatory process of the ovaries. Other studied hormones showed the development of pathological reactions in parallel with the progression of vaginal dysbiosis. Along with progressive hypoestrogenism, this indicates the switching of secretion in the ovaries from estrogens to androgens (development of hyperandrogenism), which was due to aromatase activity and was characteristic for the development of adnexitis (the effect of inflammation factors — hypoxia, intoxication, acidosis). With dysbiosis, the main stress system of the body — hypothalamic-pituitary-cortico-adrenal with initial and moderate dysbiosis, was activated, and with severe dysbiosis and, especially, bacterial vaginosis — depletion. Conclusions. On the basis of generalized data and the use of mathematical methods of analysis, the influence of hormonal indices on the state of microbiota and colonization resistance of the vagina is highlighted. An analysis of the results showed that the reaction of hormonal systems in dysbiosis and bacterial vaginosis was characterized by the development of primary hypergonadotropic hypogonadism with hypoestrogenia and hyperanorrhage; "Distress syndrome" and functional dysteriosis. Key words: bacterial vaginosis, hormonal regulation, dysbiosis