Advances in the diagnosis and treatment of nephrological diseases in children are colossal, but nevertheless, in about 23% of patients the disease has a progressive course, which significantly affects the formation of quality of life. The interstitial tissue of the kidneys is the focus of pathology in TIPP, further covering the blood vessels, lymphatic vessels and tubules of the renal stroma [5;7].Despite the successes achieved in the treatment and prevention of CTIN in children,Currently, there is no exact algorithm for diagnosing this pathology in the literature. Comparative clinical and laboratory diagnostics of the main types of tubulointerstitial nephritis is also not fully developed. There is no data on the pathogenetic relationship between tubular functions and indicators of protein metabolism in blood serum and urine in children with different forms of CTIN. The development of a new pathogenetically substantiated complex treatment for CTIN in children remains a significant research task [8;9].