The increase of mycosis and the development of resistance to usual antifungal stimulated the search for new antifungal coming from medicinal plants. This work?s aim was to evaluate the antifungal activity of aqueous and ethanolic extracts of Enantia polycarpa stem?s barks on the in vitro growth of Candida albicans, Cryptococcus neoformans, Aspergillus niger and Aspergillus flavus. Aqueous and 70% ethanolic extracts were tested on the fungi. The evaluation has been done by incorporating extracts in agar Sabouraud according the double dilution slant method. After 48 hours of incubation at 30⁰C. The germs have been sensitive to the two extracts according to a relation dose response relationship. 70% ethanolic extract (FMC=3,125 mg/mL on Candida albicans, FMC = 6,25 mg/mL on Cryptococcus neoformans and Aspergillus flavus and FMC = 12,50 mg/mL on Aspergillus niger) had the best activity. Candida albicans (FMC=3,125 mg/mL and IC50 = 1,80 mg/mL) was most sensitive. Thus, solvent hydro-alcoholic (70% ethanolic) concentrates better active ingredients of Enantia polycarpa.