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Human Lysine Demethylase Jmjd2D (Kdm4D); A Target Enabling Package

Research datakeyboard_double_arrow_right Dataset 17 Jun 2016Publisher:ZenodoFunded by:EC | ULTRA-DD
Authors: Savitsky, Pavel; Yapp, Clarence; Hatch, Stephanie B.; Oppermann, Udo; Muller-Knapp, Susanne; Johansson, Catrine; Tumber, Anthony; +6 Authors

doi: 10.5281/zenodo.1241028 , 10.5281/zenodo.1445317 , 10.5281/zenodo.1219699 , 10.5281/zenodo.1287265 , 10.5281/zenodo.1219698

Human Lysine Demethylase Jmjd2D (Kdm4D); A Target Enabling Package

Abstract

There are 4 members of the Lysine Demethylase JMJD2 (KDM4) family. SGC Oxford has expressed, purified and crystallized the catalytic domains of JMJD2A, JMJD2B, JMJD2C and JMJD2D as part of the probe programme. Fragment screening and X-ray crystallography identified a large number of binders, some of which were progressed into a medicinal chemistry programme. Despite significant effort molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.

The work at the SGC has been supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement [115766]. This document represents version 3 of the TEP datasheet and includes all updates on the project as of April 2018. For more information about TEPs and the TEP Programme, please visit https://thesgc.org/tep.

Keywords

disease, structure discovery, infectious disease, JMJD2D, malaria, chemical probe, chemical biology, structural genomics, metabolic diseases, drug target, drug discovery, neurological genetic disorders, KDM4D, target enabling package, cancer, neuropsychiatry, neuro, genetics, structure, orphan disease, protein

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citations
The total number of citations received by all articles of the researcher of interest.
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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