The use of Brophyllum pinnatum in the treatment of several ailments in traditional medicine practice is common. The effect of hydromethanolic leaf extract of Bryophyllum pinnatum on reproductive parameters of male wistar rats was investigated in this study. Male wistar rats were randomly assigned into three (3) groups. Group one which served as control received distilled water. Groups two and three received 100mg/kg body weight and 200mg/kg body weight of the extract . The extracts were administered as single oral doses for 30 and 58 days for hormonal and sperm quality studies respectively. Results obtained showed that there was significant (p<0.05) increase in LH and TET at the low dose (100mg/kg) bw. However, there was significant (p<0.05) reduction in sperm count, volume and the percentage of morphologically normal spermatozoa. The leaf extract of Brophyllum pinnatum possesses antifertility effects due to its suppressive effects on spermatogenesis in male wistar rats.