Bioadhesive systems provide intimate contact between a dosage form and the absorbing tissue, which may result in high concentration in a local area and hence high drug flux through the absorbing tissue. Example : Transdermal Drug Delivery system. The present study was carried out to investigate the Transdermal release of Metoprolol Succinate by Solvent Casting method using different polymers. From the results, it was found the liberation of drug from the formulations. All the Transdermal patches Pre-formulation and Post-formulation patches were found to be within the limits. Among all the formulations, F6 (with Sodium alginate, Gelatin, PVP K30, HPMC K4M, SLS, Urea, Tween 80 and Glycerine) emerged to be the best one, because, it exhibits the maximum percentage drug release of 98.15%. In-vitro kinetics for F6 showed that the drug mechanism was found to be Non-Fickian diffusion.