Data generated by 2D reactive, compressible, multi-species fluid model of uranium femtosecond laser ablation in an atmospheric oxygen environment. The dataset consists of a series of plain text tabular data files recorded at several time points during the simulation run. The data files are numbered according to the simulation time in nanoseconds (FFF-0100.txt is the data at 100 ns) and are given at intervals of 50 ns for the first 500 ns of simulation time, and every 100 ns thereafter, up to the total simulation time of 10000 ns. The initial conditions are provided in the first data file (FFF-0000.txt). Each data file contains spatially-resolved values of the fluid moments along with the molar concentrations of each species considered in the model (total of 30 species), given in a column format delimited by spaces. For details on the model implementation and simulation conditions, please refer to the associated manuscript.