Osteoarthritis is a degenerative bone disorder characterized by cartilage destruction and bone remodelling. Multiple risk factors like age, sex, trauma, obesity and genetic predisposing factors are linked with osteoarthritis. Inflammation and angiogenesis are the main characteristic features of osteoarthritic pathophysiology. The present research was aimed to evaluate the in vitro anti-arthritic and anti angiogenic activity of curcumin, diclofenac sodium and their combination. Anti arthritic activity was evaluated by protein denaturation using bovine serum albumin. Denaturation was induced by incubating the drugs with bovine serum albumin under experimental conditions and compared with the control. The protein denaturation was quantified by measuring their absorbance at 660nm. Percentage of Inhibition and IC50 were calculated. Anti-angiogenic effect was evaluated using Chick Chorion Allantoic Membrane (CAM) assay. Drugs were loaded on to the agar gel and aspectically inserted into CAM. Angiogenesis was evaluated by counting the number of blood vessels under microscope. The length, diameter of primary, secondary and tertiary blood vessel and CAM area of different groups were measured by using Image J software. The results demonstrates that diclofenac sodium and curcumin when given in combination induced more effective anti-arthritic and anti-angiogenic effect than the individual drugs. The results of this study highlighted the synergistic potency of diclofenac sodium and curcumin combination in attenuating arthritis and angiogenesis which can serve as a novel therapeutic strategy in treatment of osteoarthritis, Osteoarthritis is a degenerative bone disorder characterized by cartilage destruction and bone remodelling. Multiple risk factors like age, sex, trauma, obesity and genetic predisposing factors are linked with osteoarthritis. Inflammation and angiogenesis are the main characteristic features of osteoarthritic pathophysiology. The present research was aimed to evaluate the in vitro anti-arthritic and anti angiogenic activity of curcumin, diclofenac sodium and their combination. Anti arthritic activity was evaluated by protein denaturation using bovine serum albumin. Denaturation was induced by incubating the drugs with bovine serum albumin under experimental conditions and compared with the control. The protein denaturation was quantified by measuring their absorbance at 660nm. Percentage of Inhibition and IC50 were calculated. Anti-angiogenic effect was evaluated using Chick Chorion Allantoic Membrane (CAM) assay. Drugs were loaded on to the agar gel and aspectically inserted into CAM. Angiogenesis was evaluated by counting the number of blood vessels under microscope. The length, diameter of primary, secondary and tertiary blood vessel and CAM area of different groups were measured by using Image J software. The results demonstrates that diclofenac sodium and curcumin when given in combination induced more effective anti-arthritic and anti-angiogenic effect than the individual drugs. The results of this study highlighted the synergistic potency of diclofenac sodium and curcumin combination in attenuating arthritis and angiogenesis which can serve as a novel therapeutic strategy in treatment of osteoarthritis