The present study deals with the phytochemical and GC MS analysis of on medicinal plant, Psophocarpus tetragonolobus, which is commonly used in Ayurveda and sidhha forms of medicinal practice. Ethanol, methanol, hexane and water extracts of leaves of P. tertagonolobus were studied for the presence of various phytochemicals present therein. The GC MS analysis of methanol and aqueous extracts of P. tetragonolobus leaves was performed. In the ethanol fraction flavonoids, saponins and cardiac glycosides were present. In the methanol extract tannins, anthraquinones and steroids were present. In hexane fraction, flavonoids, alkaloids and triterpenoids were present. The water extract contained alkaloids, saponins, amino acids and anthraquinones. The GC MS results indicated the presence of some important biomolecules such as Catechol, N-Benzyl-2-phenethylamine, Arbutin, Tetracyclo[6.3.2.0(2,5).0(1,8)]tridecan-9-ol, 4,4-dimethyl-, Tetracyclo[6.3.2.0(2,5).0(1,8)]tridecan-9-ol, 4,4- dimethyl-, Diepicedrene-1-oxide, 1-Heptatriacotanol, Phytol, Stigmasterol in the aqueous fraction of leaves. In the Methanol fraction N-Benzyl-2-phenethylamine, Phenol, 3-methyl-5-(1-methylethyl)-, methylcarbamate, Phenol, 2,4- bis(1,1-dimethylethyl)-, 10-Methyl-8-tetradecen-1-ol acetate, 3-O-Methyl-d-glucose, 17-Octadecynoic acid, methyl ester, Hexadecanoic acid, methyl ester, Oleic Acid, 1-Monolinoleoylglycerol trimethylsilyl ether, .beta.-Sitosterol, Octasiloxane,1,1,3,3,5,5,7,7,9,9,11,11,13,13,15,15-hexadecamethyl-, alpha.-Amyrin were present. These biomolecules indicate the medicinal activities which are being claimed in the ethnobotanical practice. Key words: Psophocarpus tetragonolobus, Phytochemical, GC MS, Catechol, Catechol, Arbutin, Phytol, Stigmatsterol