This is a small subset of the RNA-seq data from a recently published macrophage study (https://doi.org/10.1038/s41588-018-0046-7) intended for quickly testing alignment and quantification methods. The fastq files only contain reads mapping to the chromosome 21 of the human genome. The dataset consists of macrophages from two individuals (eipl and fikt) profiled in two conditions: A - naive C - 5 hours after Salmonella infection The data is paired end with 1 and 2 denoting the first and second pair, respectively.